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NEDA as a Treatment Target in MS

Robert Bermel, MD, of Cleveland Clinic, emphasizes the importance of discussing treatment targets with patients, and why No Evidence of Disease Activity is a good starting point. (2:15)
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Blood Biomarkers in MS: What to Expect in the Years Ahead

In People with MS, Lower Deep Gray Matter Volumes are Associated with Depression

In this study, patients with MS who had depressive symptoms also had lower total brain and overall gray matter volumes compared with patients who were never or rarely depressed.
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Limiting Gadolinium Exposure in MS Patients

MS and the Gut Microbiome: A Potential Prognostic Marker?

Researchers examined gut microbiota in a group of patients with multiple sclerosis and found that certain characteristics at baseline were associated with worsening disability.
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Making the Most of MRI in Multiple Sclerosis

B. Mark Keegan, MD, of Mayo Clinic, describes the value of MRI in MS, including its role in diagnosis, assessing prognosis, and faciliating management decisions. (1:28)

What Stops People with MS from Exercising—and Can You Help?

Exercise can mitigate some symptoms of MS, such as fatigue, muscle weakness, and limited mobility. But many patients live a sedentary lifestyle because of their physical disabilities. These investigators found that encouragement from healthcare providers helped increase exercise participation.

Predicting Cognitive Impairment in MS

Utilizing large, multicenter MRI and clinical data, investigators employed machine learning to produce a tool for predicting cognitive impairment in MS.

Multiple Sclerosis and Stroke: Discharge Outcomes and Hyperacute Stroke Treatment

According to a study of patients with ischemic stroke, patients with multiple sclerosis have lower rates of good discharge and use of endovascular thrombectomy compared with patients without multiple sclerosis.
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In MS, MRI Trumps Clinical Attacks for Detecting Inflammatory Activity

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How Patient-Specific Factors Influence MS Risk and Progression

Keeping MS Patients with Comorbidities Out of the Hospital

Patients with multiple sclerosis often contend with conditions like asthma, diabetes, and high blood pressure, any of which could lead to hospitalization. A new study from the University of Michigan examines the unmet needs of these patients—and what may help them.
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Multiple Sclerosis and the Risk of Relapse After IVF

Family planning is never an easy undertaking, but things take a turn when fertility is a problem and the woman has MS. The question then often becomes: Will IVF treatments raise the risk of a troublesome MS relapse?

Q&A: Benjamin M. Segal, MD, on Aging and MS

With increasing age, factors such as immunosenescence and defects in mitochondria and DNA drive disease progression in MS. In this interview, Dr. Segal discusses these mechanisms in detail.

Patients with MS Have More Fractured Hips, More Falls, and are More Likely to Receive an Osteoporosis Diagnosis

These results suggest that improving documentation of osteoporosis in patients with MS will lead to better risk-mitigation plans, more appropriate treatment, and enhanced care coordination.

In MS, What is the Role of Ileal Conduit in Patients with Lower Urinary Tract Dysfunction?

Could this be the next step when conservative strategies don’t prevent complications or lead to better quality of life?
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Applications of aHSCT: Who’s Eligible?

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Abnormal Brain Scans vs Radiologically Isolated Syndrome: What You Should Know

An abnormal brain scan doesn't always mean radiologically isolated syndrome--so how can we tell? It's challenging, explains Robert Bermel, MD, of Cleveland Clinic. (2:53)
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Vitamin D Supplementation for MS Patients

Quick Quiz: How Would Your MS Patients Answer These Questions?

Our colleagues at Everyday Health surveyed thousands of patients with multiple sclerosis about their life with this neurologic disorder. See if you can correctly predict how they answered some of the survey questions.

Multiple Sclerosis: Q&A on Aquatic Exercise

Two top researchers talk about aquatic exercise as an exercise option for people with multiple sclerosis.

COVID-19 Reimmunization in MS: Should It Be Considered?

A recent study showed that a 3rd vaccine dose for SARS-CoV-2 may be of benefit in certain MS patients.

In Patients with MS, Gut Microbiota and Blood Metabolome Alterations Identified

A recent study identified alterations in the gut microbiome and blood metabolites in patients with MS.

How Does the Central Vein Sign Aid in Treating Multiple Sclerosis?

The central vein sign (CVS) may be used as a radiologic biomarker, aiding in the differentiation of MS from other diseases.
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Patient Perspectives of MS: Treatment Goals

The priorities of patients with multiple sclerosis differ depending on their lifestyle, so it's important to discuss treatment goals with each patient individually, says Robert Bermel, MD, of Cleveland Clinic. (3:27)
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B-Cell Depleting Therapies: The Most Promising Development in MS?

Gray Matter Atrophy and White Matter Lesions in Relapsing-Remitting MS

A new study from Germany examined magnetic resonance imaging data from 600 patients to attempt to learn what drives gray matter atrophy in patients with relapsing-remitting multiple sclerosis (RRMS). Here’s what they found.
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Neuropathic Pain: How to Manage it

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Neuropathic Pain: What Causes it?

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MRI in Multiple Sclerosis: New Guidelines

Experts in multiple sclerosis reviewed the evidence for the use of magnetic resonance imaging in MS, especially with regard to safety measures involving gadolinium-based contrast agents. Here are some highlights.

Multiple Sclerosis and Cognitive Impairment: What Causes it?

Researchers from the Netherlands set out to characterize the functional network changes associated with cognitive impairment in multiple sclerosis patients.
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When Should DMT Be Stopped?

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Clinically Isolated Syndrome: How to Manage it

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Clinically Isolated Syndrome: What is it?

Myelin Blistering and Its Role in the Pathophysiology of Multiple Sclerosis

A phenomenon dubbed ‘myelin blistering,’ in which the myelin sheath pulls away from its parent axon, may be the primary event in multiple sclerosis. Myelin blisters and related histologic changes are more common in the normal appearing white matter of MS patients compared to controls.
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Monitoring Patients with Radiologically Isolated Syndrome: What’s Appropriate?

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Q&A: Central Vein Sign: A Promising Imaging Biomarker in MS?

Dr. Scott D. Newsome, MD, of Johns Hopkins School of Medicine discusses the potential benefits of central vein sign as a diagnostic tool in MS.

Q&A: MS Prodrome?

Dr. Naila Makhani and Dr. Helen Tremlett discuss emerging evidence about a possible prodromal phase of MS and differentiating it from MS risk factors.
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Can We Modify Bacteria in the Gut—and Change the Course of MS?

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Reparative Therapy in Multiple Sclerosis: Early but Promising

Multiple Sclerosis and Cancer: Some Good News, Some Not

Investigators used data from nearly 54,000 patients with multiple sclerosis, matched 1:5 to controls without MS, to assess the risk of various cancer types in this group.
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In Relapsing MS, Early and Long-Term Treatment Delays Disability and Progression

A new statistical model allows for the evaluation of treatment timing and duration on long-term outcomes in MS patients. Early initiation and long treatment duration with DMT offer the strongest benefit in delaying disability and progression, with treatment duration being the most decisive factor.
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The Gut Microbiome in Patients with MS

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COVID-19 Infections in Patients on Highly Effective Treatments

Multiple Sclerosis Relapse: What Month Is It?

Understanding triggers for multiple sclerosis relapses is an ongoing process. A cohort study from Denmark investigates seasonality as a possible cause.

Relapsing-Remitting MS: Disability After 15 Years of DMT

Long-term treatment with immunotherapy reduces relapse activity and prevents at least one-fifth of neurological disability worsening in patients with RRMS.

In MS, HSCT Stems Long-term Disability

Autologous hematopoietic stem cell transplantation was shown to prevent disability worsening in a large proportion of patients with RRMS and progressive MS. It should be considered as a treatment strategy for MS that doesn’t respond to conventional therapy.