OCT Angioplasty Win; Congenital Defect Found in Bronny James; Gene Tx for Angina

— Recent developments of interest in cardiovascular medicine

Cardio Break over a computer rendering of a heart.

Cardiovascular mortality in the U.S. fell substantially from 1968 to 2019, but the pace of decline slowed in the last decade, death certificates suggest. (European Journal of Preventive Cardiology)

The evidence favors continuing SGLT-2 inhibitor therapy for heart failure even when eGFR falls low below 25 ml/min/1.73 m2, according to a pooled analysis of DAPA-HF and DELIVER. (Journal of the American College of Cardiology)

Percutaneous coronary intervention (PCI) was more successful and associated with less stent thrombosis when guided by optical coherence tomography (OCT) as opposed to traditional angiography, according to the ILUMIEN IV group. (New England Journal of Medicine)

In fact, major adverse cardiac events were down with routine OCT guidance for PCI on complex coronary artery bifurcation lesions. (New England Journal of Medicine)

Unsubstantiated heart health claims were often found on the labels of fish oil supplements on the market. (JAMA Cardiology)

Another PCSK9 inhibitor emerges, as lerodalcibep, a novel anti-PCSK9 small binding protein cut LDL cholesterol in heterozygous familial hypercholesterolemia in a phase III trial. (European Heart Journal)

ORION-8 showed that twice-yearly inclisiran (Leqvio) injections continued to confer LDL cholesterol reduction beyond 6 years, Novartis said.

A first-in-human study finds oral muvalaplin reduces lipoprotein(a) levels without safety or tolerability issues. (JAMA)

Sports cardiologists give context to the reported finding of a congenital heart defect that led to Bronny James' cardiac arrest. (Yahoo Sports)

In the observational ATHENS study, people with non-valvular atrial fibrillation who switched from apixaban (Eliquis) to rivaroxaban (Xarelto) reportedly had more stroke, systemic embolism, and major bleeding events than those staying on apixaban, Bristol Myers Squibb-Pfizer said.

People in their 80s who underwent transcatheter edge-to-edge mitral valve repair appeared to have longer lifespans in the MitraSwiss registry. (JACC: Cardiovascular Interventions)

The efficacy of mavacamten (Camzyos) was extended to Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy, the EXPLORER-CN trial showed. (JAMA Cardiology)

The antioxidant sodium thiosulfate was a flop for infarct size reduction in ST-segment elevation myocardial infarction. (JACC: Basic to Translational Science)

Investigational gene therapy encoberminogene rezmadenovec (XC001) continued to show promise for refractory angina, most recently with 6-month efficacy data from the EXACT trial, XyloCor Therapeutics announced.

A new Lancet Commission report urged a multidisciplinary strategy to prevent sudden cardiac death. (Lancet)

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    Nicole Lou is a reporter for MedPage Today, where she covers cardiology news and other developments in medicine. Follow